VI

目.錄

Contents

**篇　藥理學實驗總論

**章　實驗動物的種類和特點 ..................................................................................................................3

第二章　動物實驗的基本技術(shù) .......................................................................................................................6

**節(jié)　動物的捉拿和編號 .....................................................................................................................6

第二節(jié)　動物的給藥途徑和方法 ............................................................................................................8

第三節(jié)　動物的采血方法 .......................................................................................................................10

第四節(jié)　動物的麻醉和處死方法 ..........................................................................................................15

第三章　藥理實驗的目的和要求 ................................................................................................................18

第四章　藥理實驗設計的基本要求............................................................................................................20

第五章　藥理實驗給藥劑量設計 ................................................................................................................25

第二篇　常見藥理學實驗

實驗一　影響藥物作用的因素 .....................................................................................................................33

實驗二　普魯卡因的半數(shù)致死量測定（改良寇氏法）.........................................................................38

實驗三　磺胺嘧啶鈉在兔體內(nèi)的藥動學實驗 .........................................................................................40

實驗四　有機磷酸酯類中毒及其解救 .......................................................................................................44

實驗五　不同藥物對兔肌松作用的影響 ..................................................................................................46

實驗六　地西泮對小鼠自主活動的影響 ..................................................................................................49

實驗七　地西泮和戊巴比妥鈉的抗驚厥作用 .........................................................................................51

實驗八　阿司匹林和嗎啡鎮(zhèn)痛作用的比較..............................................................................................53

實驗九　阿司匹林對干酵母所致大鼠發(fā)熱模型的解熱作用 .............................................................56

實驗十　對乙酰氨基酚對脂多糖所致兔發(fā)熱模型的影響..................................................................58

實驗十一　利多卡因的抗心律失常作用 ..................................................................................................60

實驗十二　硝普鈉、腺苷的控制性降壓作用 .........................................................................................62

實驗十三　祛痰藥物實驗 ..............................................................................................................................64

實驗十四　硫酸鎂的導瀉作用及阿托品對腸蠕動的影響..................................................................66

實驗十五　糖皮質(zhì)激素對巴豆油所致小鼠耳腫的影響 ......................................................................68

實驗十六　地塞米松對角叉菜膠所致大鼠足腫的影響 ......................................................................70

實驗十七　胰島素的降血糖作用（試紙條法）.......................................................................................73

實驗十八　藥物不良反應 ..............................................................................................................................76

實驗十九　局部麻醉藥的毒性作用............................................................................................................78

實驗二十　氯丙嗪對乙醚麻醉作用的影響..............................................................................................80

實驗二十一　乙醚麻醉分期和麻醉前給藥..............................................................................................81

實驗二十二　硫噴妥鈉的靜脈麻醉作用 ..................................................................................................83

實驗二十三　普魯卡因和丁卡因表面麻醉作用比較 ...........................................................................85

實驗二十四　普魯卡因?qū)ν眉顾璧穆樽碜饔?.........................................................................................87

實驗二十五　腎上腺素對普魯卡因浸潤麻醉作用的影響..................................................................89

實驗二十六　氯胺酮、硫噴妥鈉對兔呼吸和循環(huán)的影響..................................................................91

實驗二十七　腎上腺素作用的翻轉(zhuǎn)............................................................................................................93

實驗二十八　小鼠肉瘤S180皮下移植瘤模型的建立 ........................................................................95

實驗二十九　小鼠肉瘤S180肺部轉(zhuǎn)移模型的建立 .............................................................................97

參考文獻 ...............................................................................................................................................................99